Status:
ACTIVE_NOT_RECRUITING
Assessment of Renal Function in Adults Born Preterm: The HAPI-Kidney Study
Lead Sponsor:
St. Justine's Hospital
Collaborating Sponsors:
Centre hospitalier de l'Université de Montréal (CHUM)
Canadian Institutes of Health Research (CIHR)
Conditions:
Prematurity; Extreme
Eligibility:
All Genders
18-40 years
Brief Summary
Every year in Canada, 1500 babies are born ≤29 weeks' gestational age (GA) and the majority survive to adulthood. Preterm birth occurs during a critical period of nephrogenesis. Antenatal and postnata...
Detailed Description
Given that preterm birth is associated with reduced nephron endowment and higher glomerular area on renal histology suggesting compensatory glomerular hyperfiltration, we postulate that : Hypothesis ...
Eligibility Criteria
Inclusion
- Born preterm ≤29 weeks or full-term at 37-41 weeks;
- For full-term controls only, birthweight ˃2500g;
- Aged 18-40 years;
- Participants with type-2 diabetes can be included.
Exclusion
- Currently pregnant due to administration of radionucleotides and impact on GRF,
- Severe neurosensory deficit preventing test completion,
- History of characterized kidney disease independent of preterm birth, including type-1 diabetes, glomerulopathies (e.g. nephrotic syndrome, glomerulonephritis), polycystic kidney disease, polycystosis, severe uropathy (Grade 4 or 5 RVU, severe hydronephrosis (SFU IV and V), posterior valve history), history of nephrectomy, exposure to radiotherapy or chemotherapy - given that we are interested in isolating the effects of preterm birth and that prevalence of these conditions is not increased in individuals born preterm,
- In case of contra-indication to MRI scanning (which should be rare in the young population studied), the participant will still be given the opportunity to complete the other examinations.
Key Trial Info
Start Date :
June 26 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 30 2025
Estimated Enrollment :
157 Patients enrolled
Trial Details
Trial ID
NCT04735315
Start Date
June 26 2021
End Date
December 30 2025
Last Update
July 11 2025
Active Locations (1)
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1
StJustine's Hospital
Montreal, Quebec, Canada, H3T 1C5