Status:
TERMINATED
Effects of Antioxidant Sugar vs Granulated Sugar on Metabolic Outcomes in Healthy and Cardio Metabolic Subjects
Lead Sponsor:
Universiti Putra Malaysia
Collaborating Sponsors:
Central Sugars Refinery Sdn Bhd, Malaysia
Conditions:
Gene Expression
Cardiometabolic Risk
Eligibility:
All Genders
18-59 years
Phase:
NA
Brief Summary
Study 1: To investigate the effects of antioxidant-rich sugar as alternative compared to granulated sugar on gene expression and other metabolic parameters in healthy subjects. The hypotheses is anti...
Detailed Description
Study 1: After being informed about the study and potential risks, written informed consent will be obtained from all subjects involved in the study. Respondents will be interviewed at Nutritional St...
Eligibility Criteria
Inclusion
- Study 1:
- Willingness to adhere to study protocol
- Healthy adults to be aged between 18 and 60 years in both genders
- Being non-smoker
- Body mass index (BMI) between 23 - 26.9 kg/m2 (overweight).
Exclusion
- Present of any kidney, liver and/or inflammatory disease (inflammatory bowel disease, Rheumatoid arthritis and etc.), thyroid disorder, diabetes (Type 1 \& Type 2), cardiovascular or metabolic disease
- Individuals with impaired glucose tolerance or with fasting blood glucose level that more than 5.2 mmol/L
- Pregnancy or lactation
- Alcohol consumption, food allergy
- Individuals who are on regular antioxidant, anti-inflammatory and /or anti-obesity drugs, receiving any glucose lowering and/or lipid lowering medications
- Change in the diet and physical activity (significant weight changes during study period)
- Subjects who habitually consumed beverages rich in sugar such as milo, Teh tarik more than 500 ml, (as tested with the FFQ)
- Study 2:
- Candidates will be screened for:
- Cardiometabolic risk factors (waist circumference, blood pressure, fasting blood glucose, triglyceride and high-density lipoprotein cholesterol)
- Pregnancy or breast feeding
- Mental health status
- Daily total sugar intake
- Inclusion Criteria:
- Malaysian, aged ≥18-59 years old
- Able to read, write and communicate well either in Malay or English
- Attained at least formal education level (secondary school and above)
- Able to use the gadgets and have access to the internet
- Presence with Cardiometabolic risk defines at least any of three out of five risk factors are present and the risk factors are:waist circumference (men: ≥90cm, women:≥80 cm); blood pressure (≥130/85 mmHg); having diabetes mellitus or fasting blood sugar (≥5.6mmol/L); triglyceride (≥1.7 mmol/L) or high-density lipoprotein (men: \<1.03 mmol/L, women: \<1.3 mmol/L).
- Daily free sugar intake ≥10% of the daily energy intake
Key Trial Info
Start Date :
February 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2022
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT04737044
Start Date
February 1 2022
End Date
July 1 2022
Last Update
February 8 2023
Active Locations (1)
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1
Universiti Putra Malaysia
Serdang, Selangor, Malaysia, 43400