Status:
WITHDRAWN
Evaluation of Innovative Combinatorial stratégies of Anti-latency and Anti-immune Activation Drugs Targeting HIV Reservoir
Lead Sponsor:
Centre de Recherches et d'Etude sur la Pathologie Tropicale et le Sida
Conditions:
HIV
Eligibility:
All Genders
18-75 years
Brief Summary
Several barriers prevent the remission of HIV infection: low level viremia, HIV latency in the genome of host infected immune cells and persistent immune activation. Targeting immune activation and vi...
Detailed Description
Despite its major benefits, cART implies mandatory lifespan treatment, toxicity, high costs and the inability to restore full-health, thus urging the need to find a cure strategy and to revisit our ap...
Eligibility Criteria
Inclusion
- Documented HIV-1 infection
- CD4+ count nadir ≥ 200 cells/mm3
- At least 4 years of suppressive ART, i.e. HIV plasma viral load (RNA) ≤ 50 copies/ml without any interruption (less than one month cumulative);1 blip/year allowed at values of maximum 1000 cp/ml
- CD4+ count ≥ 500 cells/mm3 in the 6 months prior to inclusion
- Ability and willingness to provide informed consent
Exclusion
- Active HBV and/or HCV co-infection
- Pregnancy or breast-feeding woman
- Previous immunotherapy (e.g. IL-2, IL-7) within the past year
- Participation in another clinical drug or device trial where the last dose of drug was within the past 30 days or an investigational medical device is currently implanted
- History of autoimmune disease, such as systemic lupus erythematosis (SLE) or Hashimoto's thyroiditis
- Active drug or alcohol use or dependence that, in the opinion of the center investigator, would interfere with adherence to study requirements.
Key Trial Info
Start Date :
September 15 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 15 2020
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04741100
Start Date
September 15 2020
End Date
December 15 2020
Last Update
February 5 2021
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