Status:
COMPLETED
Aerobic Exercise Training in Acute Ischaemic Stroke
Lead Sponsor:
Sheffield Hallam University
Collaborating Sponsors:
Sheffield Teaching Hospitals NHS Foundation Trust
Conditions:
Ischemic Stroke
Acute Stroke
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Stroke is a leading cause of adult disability in the UK. There are few treatment options that improve long-term disability outcomes after stroke. Animal studies indicate that aerobic exercise training...
Detailed Description
Introduction Pre-clinical studies indicate that aerobic exercise training can enhance brain repair and reduce disability when initiated early (1-7 days) after stroke. However, in the real-world clini...
Eligibility Criteria
Inclusion
- Adult (age \>18 years) patients diagnosed with acute ischaemic stroke 1-7 days previously.
- Medically stable, assessed by a stroke physician.
- Sufficient English language comprehension and cognitive ability to understand the study protocol, follow instructions, complete questionnaires and give informed consent.
- Ability to mobilise lower body limbs in a cyclical manner (at least one leg).
- Likely to be admitted to the Royal Hallamshire Hospital for at least 7 days.
Exclusion
- Haemorrhagic stroke.
- \<1 day or \>7 days after onset of stroke symptoms.
- Clinically unstable, assessed by stroke physician.
- Disability preventing unipedal cycling.
- New York Heart Failure Classification stage III/IV.
- Terminal illness (life expectancy \<6 months).
- Resting blood pressure \>180/110 mmHg.
- Uncontrolled arrhythmia causing symptoms or haemodynamic compromise.
- Unstable angina.
- Uncontrolled diabetes mellitus.
- Acute deep vein thrombosis, pulmonary embolism or pulmonary infection.
- Already participating in a clinical research trial.
- Pain during mobilisation of lower-limbs.
- Lower-limb spasticity or contracture which impairs ability to cycle.
Key Trial Info
Start Date :
April 27 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 25 2022
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04742686
Start Date
April 27 2021
End Date
August 25 2022
Last Update
August 21 2023
Active Locations (1)
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1
Royal Hallamshire Hospital
Sheffield, South Yorkshire, United Kingdom, S10 2JF