Status:
UNKNOWN
CCTA and Dynamic CT Perfusion for the Diagnosis of Myocardial Ischemia in Patients With Coronary Stents
Lead Sponsor:
Amsterdam UMC, location VUmc
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
30-80 years
Brief Summary
A single centre prospective trial in which patients with a prior PCI for stable CAD who are referred for invasive angiography will undergo state-of-the art CCTA and dynamic CT perfusion. Subsequently ...
Detailed Description
Rationale: Recent development in computed tomography (CT) hardware have fulfilled the prerequisites for clinical CT myocardial perfusion imaging (CTP). Cardiac CT, has by means of coronary computed to...
Eligibility Criteria
Inclusion
- History of PCI for stable CAD
- Referred for a diagnostic ICA.
- Age above 30 years.
Exclusion
- History of severe COPD or chronic asthma
- Pregnancy
- Renal failure (eGFR \<30 mL/min)
- Use of sildenafil (Viagra) or dipyramidol (Persantin) that cannot be terminated
- Contra-indications for β-blockers
- Allergic reaction to iodized contrast
- Concurrent or prior (within last 30 days) participation in other research studies using investigational drugs
- Claustrophobia
- Significant co-morbidities
- Atrial fibrillation, second or third degree atrioventricular block
- Tachycardia
- Acute myocardial infarction
- History of CABG
- Heart failure
- Cardiomyopathies
- Previous radiation exposure in the diagnostic work-up
- Unable to give informed consent
- Indispensable follow-up with (serial) CT scans for non-cardiac related condition
Key Trial Info
Start Date :
October 25 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 1 2024
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT04742933
Start Date
October 25 2021
End Date
April 1 2024
Last Update
October 12 2021
Active Locations (1)
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1
Amsterdam UMC, location VUMC
Amsterdam, Netherlands, 1081 HV