Status:
RECRUITING
HIP Fracture Accelerated Surgical TreaTment And Care tracK 2 Trial
Lead Sponsor:
Population Health Research Institute
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Conditions:
Hip Fractures
Myocardial Injury
Eligibility:
All Genders
45+ years
Phase:
NA
Brief Summary
The HIP ATTACK-2 trial is a multicentre, international, parallel group randomized controlled trial to determine whether accelerated surgery for hip fracture in patients with acute myocardial injury is...
Eligibility Criteria
Inclusion
- age ≥45 years;
- diagnosis of hip fracture during working hours with a low-energy mechanism requiring surgery;
- troponin elevation ( at least one troponin measurement above the upper limit of normal occurring from the time of hip fracture to the time of randomization); and
- informed consent.
Exclusion
- taking a therapeutic dose of an anticoagulant for which no reversing agent is available and the anesthesiologist or surgeon believe surgery within 6 hours of eligibility criteria met would not be safe;
- patients on a therapeutic vitamin K antagonist with a history of heparin induced thrombocytopenia (HIT);
- patients with peri-prosthetic fracture, open fracture or bilateral fractures;
- patients requiring an emergency surgery for another reason (e.g., subdural hematoma);
- patients with acute myocardial infarction deemed to be clinically unstable, with a mechanical complication (i.e., acute papillary muscle rupture, ventricular septal defect), ST elevation myocardial infarction, or cardiogenic shock;
- patients refusing consent; or
- patients previously enrolled in HIP ATTACK-2.
Key Trial Info
Start Date :
November 22 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 31 2027
Estimated Enrollment :
1100 Patients enrolled
Trial Details
Trial ID
NCT04743765
Start Date
November 22 2021
End Date
May 31 2027
Last Update
October 1 2025
Active Locations (70)
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1
Chandler Regional Medical Center
Chandler, Arizona, United States, 85224
2
The Regents of the University of California
Davis, California, United States, 95618
3
Yale New Haven Hospital
New Haven, Connecticut, United States, 06520
4
Emory University at Grady Memorial Hospital
Atlanta, Georgia, United States, 30322