Status:
COMPLETED
Effects of Ketones on Muscle Wasting During Caloric Restriction in Lean Females
Lead Sponsor:
KU Leuven
Conditions:
Muscle Wasting
Protein Intake
Eligibility:
FEMALE
18-40 years
Phase:
NA
Brief Summary
Because of these anabolic properties of ketone bodies and the fact that ketone bodies prevent muscle protein breakdown for gluconeogenesis during energetic stress, ketone bodies can be a promising str...
Detailed Description
Thermodynamics state that body mass declines during periods in which energy expenditure exceeds energy intake. This negative energy balance can be obtained either by reducing energy intake, called cal...
Eligibility Criteria
Inclusion
- Females between 18 and 40 years old
- Fat percentage between 16 and 25%
- Regularly involved in physical activity ( \> 6 h/week)
- Use of hormonal contraceptives
- Good health status confirmed by a medical screening
- Stable body weight during the last 3 months prior to the study, i.e. no changes \> 2 kg
Exclusion
- Smoking
- Obsessive pursuit for thinness, evaluated by the Eating Disorder Inventory 3 (EDI-3) 'Pursuit of leanness' (i.e a score higher than 26/32) (see Appendix 5)
- Intake of any medication or nutritional supplement that is proven to affect exercise performance, except oral contraceptives
- Blood donation during the study
- Current participation in another research trial
- Any other argument to believe that the subject is unlikely to successfully complete the full study protocol
Key Trial Info
Start Date :
January 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2019
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT04744142
Start Date
January 1 2018
End Date
June 1 2019
Last Update
February 8 2021
Active Locations (1)
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1
KU Leuven
Leuven, Vlaams-brabant, Belgium, 3000