Status:
RECRUITING
Pharmacokinetics of Twice or Once Daily DTG (50mg) in Children With HIV and TB
Lead Sponsor:
University of KwaZulu
Collaborating Sponsors:
Centre for the AIDS Programme of Research in South Africa
Conditions:
Tuberculosis
Hiv
Eligibility:
All Genders
23-18 years
Phase:
PHASE4
Brief Summary
Stage 1 proposed study will provide evidence to support the use of twice-daily dose 50mg DTG in children (20-35kgs) co-treated with RIF. Note: An amendment has been added to include children from 3kg...
Detailed Description
This is a single centre, open-label, non-randomised, prospective study evaluating the steady-state pharmacokinetics of twice-daily dose DTG administered during concurrent RIF treatment and assessing s...
Eligibility Criteria
Inclusion
- Children \<18 years with confirmed HIV-1 infection weighing 20-35kg ART-naive or experienced, with plans to use DTG for HIV treatment
- Diagnosis of TB disease with clinician initiating rifampicin-containing first-line therapy
- Parents/legal guardians/caregivers and children give informed written consent (or assent, where applicable) to be in the study
- Girls who have reached menses must have a negative pregnancy test at screening and be willing to adhere to two effective methods of contraception (barrier and a non-barrier form of contraception during the study, starting at least 14 days prior to enrolment) if sexually active. The parents/caregivers will be counselled together with the child if the child tests positive in order to reduce any social harm which may arise.
Exclusion
- History or presence of known allergy or contraindications to DTG
- Alanine aminotransferase (ALT) ≥5 times the upper limit of normal (ULN), OR ALT ≥3xULN and bilirubin ≥2xULN
- Severe hepatic impairment or unstable liver disease (as defined by the presence of ascites, encephalopathy, coagulopathy, hypoalbuminaemia, oesophageal or gastric varices, or persistent jaundice), known biliary abnormalities (except for Gilbert's syndrome or asymptomatic gallstones)
- Pregnancy or breastfeeding
- A concurrent illness that could influence drug PK, i.e. severe diarrhoea, vomiting, renal or liver disease
- Treatment with concomitant medications known to have interactions with DTG
- Participants that are eligible for the study but refuse to give consent and/or assent
Key Trial Info
Start Date :
August 19 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 31 2025
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04746547
Start Date
August 19 2021
End Date
July 31 2025
Last Update
February 1 2024
Active Locations (1)
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1
King Edward VIII Hospital
Durban, KwaZulu-Natal, South Africa, 4001