Status:
RECRUITING
Coronary Computed Tomographic Angiography in Intermediate-risk Chest Pain Patients
Lead Sponsor:
Karolinska Institutet
Conditions:
Chest Pain
Acute Coronary Syndrome
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The aim is to determine whether a diagnostic strategy including early coronary computed tomographic angiography in intermediate-risk patients presenting to the Emergency Department with chest pain red...
Detailed Description
Patients presenting to the ED with chest pain or other symptoms suggestive of ACS, without acute MI but with an intermediate risk (HEART-score \>3) will after written informed consent be randomized to...
Eligibility Criteria
Inclusion
- Age≥18 years.
- Within 24 hours from presenting to the ED with chest pain or other symptoms suggestive of coronary artery disease (CAD)
- HEART-score \>3 (according to http://www.heartscore.nl/)
- Written informed consent obtained
Exclusion
- Any condition that may influence the patient's ability to comply with study protocol.
- Acute MI
- Known obstructive CAD (\>50%) or previous PCI or CABG.
- Clear alternative diagnosis
- Estimated glomerular filtration rate (eGFR) \< 30 ml/min/1.73m2
- Major allergy to iodinated contrast media
- Circumstances making high quality images unlikely.
- Not a Swedish resident with a personal ID-number.
- Pregnancy or breast feeding
- Further investigation for CAD not indicated, due to limited life expectancy, quality of life or functional status
- Previous inclusion in the trial
Key Trial Info
Start Date :
January 21 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
1600 Patients enrolled
Trial Details
Trial ID
NCT04748237
Start Date
January 21 2021
End Date
December 1 2025
Last Update
August 20 2024
Active Locations (1)
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1
Danderyd Hospital
Stockholm, Sweden, 18288