Status:
UNKNOWN
The Role Of Neutrophil Proteases As Global Regulators Of Il-1 Family Cytokine Activity In Skin Disorders
Lead Sponsor:
St. James's Hospital, Ireland
Collaborating Sponsors:
Science Foundation Ireland
University of Dublin, Trinity College
Conditions:
Psoriasis Vulgaris
Atopic Dermatitis
Eligibility:
All Genders
18+ years
Brief Summary
Pro-inflammatory cytokines are critically important drivers of inflammatory and autoimmune diseases and cytokine-targeted biologics have been transformative in the treatment of several inflammatory an...
Detailed Description
Neutrophils, the 'first responder' cells of the immune system are recruited rapidly to sites of infection or inflammation. Neutrophil granule proteases, cathepsin G, elastase and proteinase-3, are tho...
Eligibility Criteria
Inclusion
- Have psoriasis, atopic Dermatitis or ichthyosis vulgaris with visible skin lesions, preferably on the forearm which are amenable to sampling.
- Healthy control group without any skin disease.
Exclusion
- Under 18 years old
- Fully treated skin disease without active lesions
Key Trial Info
Start Date :
March 2 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2021
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04750161
Start Date
March 2 2021
End Date
June 1 2021
Last Update
March 5 2021
Active Locations (1)
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1
Clinical Research Facility, St James Hospital
Dublin, Ireland