Status:
COMPLETED
Platelet-rich Plasma and Synovial Cytokines in Knee Osteoarthritis
Lead Sponsor:
South Valley University
Conditions:
Knee Osteoarthritis
Eligibility:
All Genders
25-65 years
Phase:
NA
Brief Summary
A prospective study was performed on 90 patients were included and categorized into mild (30 cases, moderate (30 cases) and severe (30 cases) knee OA. Three intra-articular (I.A) injections of PRP, 2 ...
Detailed Description
Background: Osteoarthritis (OA) is a multifactorial disease that commonly affects the knee. Tumor necrosis factor-α (TNF-α) is able to regulate inflammation in OA. Macrophage migration inhibitory fact...
Eligibility Criteria
Inclusion
- • All patients have unilateral knee OA
Exclusion
- Polyarticular disease.
- Knee arthroscopy in the previous year.
- HA or steroid IA penetration in the preceding 3 months.
- History of infectious disease and autoimmune disorders such as diabetes, rheumatoid arthritis.
- Hematologic diseases (coagulopathy).
- Serious cardiovascular diseases , infections or immunodepression.
- Anticoagulant therapy or an anti-aggregating agent.
- Uuse of non-steroidal anti-inflammatory drugs 2 weeks prior to blood sampling.
- \< 10 g / dL of hemoglobin
Key Trial Info
Start Date :
February 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 14 2020
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT04754685
Start Date
February 1 2019
End Date
March 14 2020
Last Update
February 15 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Faculty of Medicine, South valley University
Qina, Qena Governorate, Egypt, 83523