Status:
COMPLETED
The Effect of Orally Administrated Nitrate on Renal Parameters and Systemic Haemodynamics
Lead Sponsor:
Frank Mose
Collaborating Sponsors:
Herning Hospital
Conditions:
Hypertension
Eligibility:
All Genders
18-64 years
Phase:
NA
Brief Summary
Treatment with nitrate has shown to lower blood pressure in both healthy subjects and hypertensive patients.Beside this nitrate have also shown to decrease arterial stiffness and improve endothelial f...
Detailed Description
Inorganic nitrate reduces blood pressure and improves endothelial function in both healthy subjects and hypertensive patients. This effect is thought to be caused through bioconversion to nitric oxid...
Eligibility Criteria
Inclusion
- Age 18-64 years
- BMI 18,5-30
- Normotensive
- Women must use contraception
Exclusion
- Tobacco smoking (Non-smokers in more than 3 months can be included)
- Medicine- or drug abuse
- Alcohol abuse \>7 units for women \>14 units for men
- Medical treatment (over the counter medication will evaluated whether or not it is grounds for exclusion) within 2 weeks before the trail period starts except contraception.
- Pregnancy or nursing
- Neoplastic disorders
- Significant clinical signs of heart-, lung-, liver-, kidney-, endocrine- or brain disorders
- Clinically significant abnormal findings in screening blood samples, urine sample or ECG - Donation of blood within 1 month of the first day of investigation.
- Allergy against compounds in investigational medicine
Key Trial Info
Start Date :
September 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 15 2020
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT04755400
Start Date
September 1 2018
End Date
March 15 2020
Last Update
February 21 2021
Active Locations (1)
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1
Godstrup Hospital
Herning, Denmark, 7400