Status:
UNKNOWN
Prognostic Factors for Treatment Responses in Patients With Active Lupus Nephritis at Sohag University Hospital
Lead Sponsor:
Sohag University
Conditions:
We Aim to Examine the Predictors of Sustained Complete Renal Remission in Patients With Lupus Nephritis at Sohag University Hospital
Eligibility:
All Genders
14-60 years
Brief Summary
Systemic lupus erythematosus (SLE) is an autoimmune disease which may give rise to multiple organ involvement because of immune complex deposits. Lupus nephritis (LN) is one of the severe manifestatio...
Detailed Description
This study will be prospectively analyzing the clinical data of LN patients who received standard immunosuppressive therapy and were regularly followed up at our center for more than six months. These...
Eligibility Criteria
Inclusion
- o Patients diagnosed with LN at Sohag University Hospital
- Patients in regular follow-up for more than six months after immunosuppressive therapy
- Baseline urinary protein/creatinine ratio (UPCR) more than 1 g/g
- Baseline C3 less than 55 mg/ dl
- No change in immunosuppressive therapy within six months
Exclusion
- o Patients with incomplete pathological data and the number of glomeruli being \<10 per biopsy specimen
- Age \<14 years old End-stage renal disease (ESRD) status on admission (sustained estimated glomerular filtration rate (eGFR) \<15 ml/min per 1.73m2)
- Patients with advanced comorbid conditions like advanced liver cirrhosis or heart failure or malignancy
Key Trial Info
Start Date :
February 15 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 15 2023
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04756492
Start Date
February 15 2021
End Date
February 15 2023
Last Update
February 16 2021
Active Locations (1)
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1
Sohag University
Sohag, Egypt, 088