Status:
UNKNOWN
Multimodal Functional Imaging Combined With Metabolomics in Predicting the Efficacy of nCRT for Locally Advanced ESCC
Lead Sponsor:
RenJi Hospital
Conditions:
Esophageal Squamous Cell Carcinoma
Eligibility:
All Genders
18-75 years
Brief Summary
Esophageal cancer (EC) is the seventh most frequently diagnosed cancers and the sixth leading causes of cancer death worldwide . It is one of the most common malignancy in China, with the third highes...
Eligibility Criteria
Inclusion
- Pathologically confirmed esophageal squamous cell carcinoma；
- AJCC 7th edition staging T3-T4a or N+；
- No radiotherapy or chemotherapy in the past；
- 18-75 years old；
- Hematology, biochemical and organ function indicators meet the following requirements: 1) White blood cells ≥ 3.0 x109/ L; 2)neutrophil cells ≥ 1.5 x109/ L; 3) Platelet count ≥85 x109/L; 4) Hemoglobin ≥90 g/L; 5) Total bilirubin ≤1.5 times normal value; 6) ALT≤ 1.5 x normal value; AST ≤1.5 times the normal value; 7) Serum creatinine ≤1.5 times the normal value, and creatinine clearance rate (Ccr) ≥60ml/min (Cockcroft-Gault);
- ECOG score 0-1 points;
- Able to eat a semi-liquid diet；
- sign an informed consent.
Exclusion
- Have received radiotherapy or systemic chemotherapy;
- During pregnancy or lactation;
- Uncontrollable serious medical diseases;
- Unable to sign informed consent;
- With distant metastasis;
- Suffering from the second type of malignant tumor (except skin squamous cell carcinoma and carcinoma in situ of other organs) within the past 5 years；
- Those who cannot receive MRI examination;
- Chemotherapy drugs or contrast agents Allergic.
Key Trial Info
Start Date :
January 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2022
Estimated Enrollment :
118 Patients enrolled
Trial Details
Trial ID
NCT04759235
Start Date
January 1 2020
End Date
December 31 2022
Last Update
February 18 2021
Active Locations (1)
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1
Renji Hospital
Shanghai, Shanghai Municipality, China, 200127