Status:
NOT_YET_RECRUITING
Amyloid Proteins From Medullary Thyroid Cancer and Laryngeal Amyloidosis
Lead Sponsor:
The Leeds Teaching Hospitals NHS Trust
Collaborating Sponsors:
University of Leeds
Conditions:
Amyloid
Medullary Thyroid Cancer
Eligibility:
All Genders
18+ years
Brief Summary
Using excess tumour samples that contain amyoid, from patients with Medullary Thyroid Cancer, we aim to determine the structures of ex vivo amyloid fibrils from human tumour tissue samples and compare...
Detailed Description
This is an anonymous, voluntary inclusion, laboratory based, basic science research study. Appropriate patients who meet the inclusion criteria and complete the consent process will be asked to donate...
Eligibility Criteria
Inclusion
- Diagnosed with known or suspected MTC or LA
- Age \>= 18 years, no upper age limit
- Able to provide informed consent for both surgical treatment and inclusion into this study
- For MTC patients, treatment recommendation from the Thyroid MDT is for either hemithyroidectomy or total thyroidectomy
- for LA patients, agreement with their attending clinician to undergo surgical debulking of disease under general anaesthetic. The procedure is called 'microlaryngoscopy and biopsy/debulking'
Exclusion
- No known or suspected diagnosis of MTC or LA
- Age \<18 years
- Unable to provide informed consent
- Treatment recommendation from Thyroid MDT is for any treatment excluding primary surgery (ie palliation, best supportive care, chemotherapy, radiotherapy etc)
- For LA patients, no agreement between patient and attending clinician to proceed with surgery as primary treatment.
Key Trial Info
Start Date :
February 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 1 2026
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT04760171
Start Date
February 1 2021
End Date
February 1 2026
Last Update
February 18 2021
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