Status:
RECRUITING
CMR Versus CT in Coronary Artery Disease
Lead Sponsor:
University of Leicester
Collaborating Sponsors:
HeartFlow, Inc.
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
18+ years
Brief Summary
CONCORD is a prospective observational study evaluating the diagnostic accuracy of cardiovascular magnetic resonance (CMR) and computed tomography with fractional flow reserve (CT-FFR) in patients wit...
Detailed Description
In patients with suspected coronary artery disease (CAD), CT coronary angiography (CTCA) provides excellent sensitivity and negative predictive value, enabling the safe exclusion of significant CAD. H...
Eligibility Criteria
Inclusion
- Patients aged ≥18 years
- Referred for invasive coronary angiography for investigation of chest pain
Exclusion
- Recent acute coronary syndrome (\< 6 months)
- Previous coronary artery bypass grafting
- Severe claustrophobia
- Absolute contraindications to CMR - those with MR conditional or safe devices will be included
- Second-/third-degree atrioventricular block
- Severe chronic obstructive pulmonary disease
- Moderate-severe asthma
- Estimated glomerular filtration rate \<30 ml/min/1.73m2
- Women who are pregnant, breast-feeding or of child-bearing potential( premenopausal women)
- Contraindication to iodinated contrast
- Participation in a research study involving an investigational product in the past 12 weeks
Key Trial Info
Start Date :
November 5 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 30 2025
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT04761991
Start Date
November 5 2020
End Date
November 30 2025
Last Update
July 1 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Glenfield Hospital
Leicester, Leics, United Kingdom, LE3 (QP