Status:
ACTIVE_NOT_RECRUITING
Paediatric Sjögren Syndrome Cohort Study and Repository (PaedSSCoRe)
Lead Sponsor:
University College, London
Collaborating Sponsors:
Cambridge University Hospitals NHS Foundation Trust
Children's Health Ireland
Conditions:
Sjogren's Syndrome Childhood-onset
Eligibility:
All Genders
6+ years
Brief Summary
Sjögren syndrome (SS) in adults is characterised by inflammation of the exocrine glands, principally the salivary and lacrimal glands resulting in xerostomia (dry mouth) and xerophthalmia (dry eyes).I...
Eligibility Criteria
Inclusion
- All recruited patients should be diagnosed with Sjogren's syndrome alone or in association with other autoimmune conditions (rheumatic or not) based on their rheumatologist opinion or have clinical and serological/imaging features which in the opinion of their clinician raise the suspicion of Sjogren's syndrome.
- Patients with symptoms onset /imaging, serological and glandular biopsy abnormalities suggestive of SS (suspected SS) or SS diagnosis made by expert clinicians prior to age 18
- Patients/ Carers who can provide informed consent and agree to provide access to the results of their routine care investigations for research purposes irrespective of being able provide blood or saliva samples.
- Patients of 6 years or age or above
Exclusion
- 1\. Inability to provide informed consent or have informed consent provided on their behalf.
Key Trial Info
Start Date :
January 11 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 10 2030
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT04762108
Start Date
January 11 2020
End Date
January 10 2030
Last Update
April 19 2021
Active Locations (8)
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1
Children's Health Ireland (CHI) at Crumlin
Dublin, Ireland
2
Cambridge University Hospitals NHS Foundation Trust
Cambridge, United Kingdom
3
Great Ormond Street Hospital For Children NHS Foundation Trust
London, United Kingdom
4
University College London Hospital
London, United Kingdom