Status:
RECRUITING
Doxycycline Intervention for Bacterial STI ChemoprOphylaxis (DISCO)
Lead Sponsor:
Jonathan Troy Grennan
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Conditions:
Bacterial Sexually Transmitted Diseases
Eligibility:
MALE
18+ years
Phase:
NA
Brief Summary
There is a growing epidemic of the bacterial sexually transmitted infections (STIs) syphilis, chlamydia and gonorrhea worldwide; similarly concerning trends have been noted in Canada, where increases ...
Detailed Description
With the rising rates of STIs among gbMSM populations in Canada, there is an urgent need for novel interventions to prevent significant sequelae (e.g. neurosyphilis) and onward transmission of untreat...
Eligibility Criteria
Inclusion
- Males, ≥ 18 years of age;
- Any sexual activity (i.e. oral sex, insertive or receptive anal sex, with or without a condom) with more than one male partner in the preceding 12 months;
- Intention to remain sexually active with more than one male partner in the next 12 months;
- At least one prior episode of a previously diagnosed and adequately treated syphilis, gonorrhea or chlamydia infection within 12 months prior to screening.
Exclusion
- Known allergy to doxycycline or tetracyclines;
- Existing chronic or intermittent tetracycline or doxycycline use (e.g. for chronic osteomyelitis, acne).
- Use of medications which could lower doxycycline levels, including barbiturates, phenytoin and carbamazepine.
- Individuals currently using isotretinoin;
- Any individual capable of becoming pregnant.
Key Trial Info
Start Date :
June 2 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2027
Estimated Enrollment :
560 Patients enrolled
Trial Details
Trial ID
NCT04762134
Start Date
June 2 2023
End Date
June 30 2027
Last Update
August 5 2024
Active Locations (6)
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1
Sheldon Chumir Centre
Calgary, Alberta, Canada
2
BC Centre for Disease Control
Vancouver, British Columbia, Canada, V5Z4R4
3
St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada
4
The Ottawa Hospital
Ottawa, Ontario, Canada