Status:
COMPLETED
Ciprofloxacin in Drug-resistant Epilepsy
Lead Sponsor:
Mazandaran University of Medical Sciences
Conditions:
Epilepsy Intractable
Eligibility:
All Genders
16-50 years
Phase:
NA
Brief Summary
This study aims to investigate the effect of a short-term prescription of ciprofloxacin on intestinal microbial pattern and seizure frequency of patients with drug-resistant epilepsy.
Eligibility Criteria
Inclusion
- Drug-resistant epilepsy with frequency of at least 2 seizure/Week
- Acceptance of patients or his/her guardian (Signing informed consent)
Exclusion
- Hypersensitivity to ciprofloxacin or other fluoroquinolones
- History of tendon, renal, hepatic or cerebrovascular disease, organ transplantation or myasthenia gravis
- Usage of medications with interaction to ciprofloxacin
- No reliable contraception
- Pregnancy or breastfeeding
- Being under treatment with corticosteroid
- Usage of antibiotics in recent 2 months or need to use it during the study
- Patients who are candidate for epilepsy surgery or other nonmedical treatments
- Change in anti-seizure medications (ASMs) during recent month
- Patients who will need changes in ASMs dose during study
Key Trial Info
Start Date :
October 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2021
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT04763070
Start Date
October 1 2020
End Date
June 1 2021
Last Update
June 7 2021
Active Locations (1)
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1
Bu Ali Sina hospital
Sari, Mazandaran, Iran, 4815838477