Status:
COMPLETED
Tumor Heterogeneity in Diffuse Large B-cell Lymphoma in Relation to CNS Involvement and Cell-free DNA
Lead Sponsor:
Herlev Hospital
Conditions:
Lymphoma, Large B-Cell, Diffuse
Eligibility:
All Genders
18+ years
Brief Summary
The aim of the project is to clarify whether DLBCL exhibits mutational diversity among different lymph node tumors in one and the same patient. It is desired to find out whether a possible difference ...
Detailed Description
Only about 60% of patients with diffuse large B-cell lymphoma (DLBCL) are cured with standard chemo- and immunotherapy, with R-CHOP(Rituximab, cyclophosphamide, doxorubicin hydrochloride, oncovin, pre...
Eligibility Criteria
Inclusion
- Diagnosed with DLBCL
- Immunochemotherapy (rituximab and CHOP-like chemotherapy) planned and not yet initiated (pretreatment with prednisolone is allowed)
- Age ≥ 18 years
- More than 1 lymphoma site accessible for biopsy
- Patient must consent to permit genetic analysis of their tumor biopsies
- Patient must consent to additional biopsies and blood samples
- Tumor biopsy and/or bone-marrow biopsy used for diagnosis available
- Patient must consent to access of their medical records to monitor the clinical process
- Written informed consent
- Baseline 18FDG-PET/CT available
Exclusion
- History of previous or current malignancies
- Other previous/current hematological malignancies or inflammatory disease
- HIV
- Concurrent diagnosis of follicular lymphoma or other indolent lymphomas (composite histology)
- If the patient is deemed to have an acute treatment need, the patient cannot be included in the project.
- Patients on blood thinners, which must be paused before an additional biopsy, causing too much delay in initiating treatment will be excluded
- \-
Key Trial Info
Start Date :
January 12 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2023
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT04763148
Start Date
January 12 2022
End Date
March 1 2023
Last Update
March 6 2023
Active Locations (1)
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1
Department of Hematology, Rigshospitalet
Copenhagen, Denmark, 2100