Status:
COMPLETED
The Efficacy of N-acetylcysteine on Alleviating Symptom Caused by Lugol Chromoendoscopy
Lead Sponsor:
Xijing Hospital of Digestive Diseases
Conditions:
Esophageal Squamous Cell Carcinoma
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Lugol chromoendoscopy is essential in detecting and characterizing squamous cell carcinoma of esophagus. Esophageal irritating symptom has been reported as an common adverse event, which could be alle...
Eligibility Criteria
Inclusion
- Patients at risk of esophageal squamous cell cancer including those over 50 years old, or over 45 years old with family history of esophageal squamous cell cancer;
- Patients with suspected esophageal lesions by screening endoscopy;
- Patients requiring surveillance after endoscopic resection or radiotherapy for esophageal squamous cell cancer one year later。
Exclusion
- Patients allergic to iodine or with hyperthyroidism;
- Patients with advanced esophageal cancer, esophageal varices, esophageal ulcer or other conditions inadvisable for Lugol chromoendoscopy;
- Patients with severe gastroesophageal reflux disease or reflux symptoms which may interfered with the outcome measures of current study;
- Patients with postoperative esophageal stenosis affecting endoscopic observation;
- Patients with serious comorbidities that cannot tolerate un-sedated gastroscopy;
- Patients who could not cooperate with the observation including patients with mental disorders, severe neurosis or dysgnosia;
- Patients undergoing sedation or general anesthesia during endoscopy.
- Patients who do not agree to sign informed consent forms or follow the trial requirement.
Key Trial Info
Start Date :
February 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 31 2021
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT04764643
Start Date
February 1 2020
End Date
May 31 2021
Last Update
January 30 2023
Active Locations (1)
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1
Xijing Hospital of Digestive Disease
Xi'an, Shaanxi, China, 710032