Status:
RECRUITING
Evaluate the Effect of Atorvastatin on Cerebrovascular Reactivity in Mild Cognitive Impairment (MCI)
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
The Richman Family Precision Medicine Center of Excellence in Alzheimer Disease
Conditions:
Mild Cognitive Impairment
Eligibility:
All Genders
60-95 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to evaluate the effect of atorvastatin on brain vessel reactivity and with it on blood flow in people with mild cognitive impairment.
Detailed Description
Participants are first being informed about potential benefits and risks of the study and are required to give written consent. After that participants will undergo detailed phone screen to determine ...
Eligibility Criteria
Inclusion
- Inclusion Criteria are chosen to include participants with MCI, enriched for vascular risk factors:
- MCI defined by Clinical Dementia Rating (CDR) of 0.5 or 1.0.
- Memory, processing speed, executive function, language - cognitive scores \> 1.5 standard deviations below age-education norms.
- Not demented by history.
- Not taking statins currently or in the last 6 months.
- Cognitive/functional impairment not likely due to another neurological disease or delirium.
- Exclusion Criteria:
- Taking a statin currently or have taken a statin in the last 6 months.
- Contraindications to taking a statin.
- Transplant patient taking cyclosporine.
- Unable to undergo MRI procedures (such as having an implanted pacemaker or defibrillator or stimulator or having non MRI compatible metal).
- Diagnosis of dementia by history.
- Current diagnosis of substance abuse.
- History of stroke or myocardial infarction in past 6 months.
- History of HIV.
Exclusion
Key Trial Info
Start Date :
May 21 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04765137
Start Date
May 21 2021
End Date
December 31 2026
Last Update
August 6 2025
Active Locations (1)
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1
Johns Hopkins University, Bayview Medical Center
Baltimore, Maryland, United States, 21224