Status:
RECRUITING
Evaluation of Brain Changes in ALL Patients on Therapy
Lead Sponsor:
Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Conditions:
Acute Leukemia
Eligibility:
All Genders
6-18 years
Phase:
NA
Brief Summary
The study is aimed at assessing changes in the brain of patients from 6 to 18 years old with a diagnosis of acute lymphoblastic leukemia during chemotherapy.
Detailed Description
Children with acute lymphoblastic leukemia receive long-term combined chemotherapy treatment, one of the main part of this treatment is methotrexate. Methotrexate can cause acute, subacute, and long-t...
Eligibility Criteria
Inclusion
- patients from 6 to 18 years old
- diagnosis of acute lymphoblastic leukemia during chemotherapy
Exclusion
- patients less then 6, and older then 18 years old
- patients who cannot perform the study MRI without general anesthesia
- Refusal to sign informed consent.
- The presence of absolute contraindications to MRI studies.
- Extremely serious condition of the patient.
Key Trial Info
Start Date :
February 16 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 21 2026
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT04767152
Start Date
February 16 2021
End Date
January 21 2026
Last Update
October 30 2023
Active Locations (1)
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1
Dmitry Rogachev Federal Research and Clinical Centre of Paediatric Haematology, Oncology and Immunology
Moscow, Russia, 117997