Status:
RECRUITING
Fear and Avoidance in PTSD Patients
Lead Sponsor:
The University of Texas Health Science Center, Houston
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Post Traumatic Stress Disorder
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
The purpose of this research study is to study how the brain learns to avoid certain stimuli or situations using an experimental paradigm. The big goal is to measure brain responses and subject's feel...
Detailed Description
This study aims to study the neural correlates of avoidance learning using a recently validated conditioning and active avoidance paradigm (CAAP). The overarching objective is to measure the neural co...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- 18 - 70 years of age
- Female or Male
- Inclusion Criteria: PTSD Subjects
- a. Diagnosis of current PTSD
- Inclusion Criteria: Trauma-exposed healthy controls (TEHC)
- SCID diagnosis consistent with no current psychiatric disorders, and no current PTSD
- History of trauma exposure
- Inclusion Criteria: Healthy controls (HC)
- SCID diagnosis consistent with no current psychiatric disorders ("Axis I" disorders).
- No history of trauma exposure
- Willing and able to provide informed consent.
- Exclusion Criteria for ALL subjects:
- History of neurologic disease (e.g. tic disorder)
- Current significant suicidal ideation, plan or intent or suicidal behavior in past 6 months based on CSSRS or Self-injurious behavior that involves suicidal intent, requires medical attention, or occurs daily
- History of seizure or significant head trauma
- History of the serious/significant psychiatric diagnosis ("Axis I" disorders)
- Use of neuroleptics within one year prior to study
- Current substance use (assessed by urine toxicology; positive urine toxicology screen for any substance, with the exception of THC). Per PI judgement and approval: if urine toxicology is positive for a substance, participant may be eligible to proceed with study provided their urine toxicology (or saliva test for THC) is negative at experimental visit(s)
- Pregnancy (to be ruled out by urine ß-HCG)
- Metallic implants or devices contraindicating magnetic resonance imaging
- High risk of adverse emotional or behavioral reaction, and/or an inability to understand study procedures or the informed consent process
- Additional exclusion criteria for Trauma-exposed healthy controls (TEHC) group and Healthy controls (HC) group:
- Current psychiatric diagnosis ("Axis I" diagnoses)
Exclusion
Key Trial Info
Start Date :
September 9 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2027
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT04770584
Start Date
September 9 2021
End Date
January 1 2027
Last Update
April 11 2025
Active Locations (1)
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1
UTHealth Houston
Houston, Texas, United States, 77054