Status:
RECRUITING
Population Pharmacokinetics of Commonly Used Antimicrobial Agents in Children of Bacterial Meningitis With Augmented Renal Clearance
Lead Sponsor:
Shandong University
Collaborating Sponsors:
Children's Hospital of Chongqing Medical University
Conditions:
Bacterial Meningitis
Augmented Renal Clearance
Eligibility:
All Genders
2-18 years
Brief Summary
The investigator's purpose is to study the population pharmacokinetics of commonly used antimicrobial agents in children of bacterial meningitis with augmented renal clearance and assess dosage indivi...
Detailed Description
The investigator's purpose is to study the population pharmacokinetics of meropenem, vancomycin, ceftazidime, ceftriaxone, ceftizoxime and linezolid in children of bacterial meningitis with augmented ...
Eligibility Criteria
Inclusion
- Children have been diagnosed with bacterial meningitis with augmented renal clearance (eGFR ≥ 160 mL/(min\*1.73m2));
- Age: 2 months-18 years;
- Meropenem, vancomycin, ceftazidime, ceftriaxone, ceftizoxime and/ or linezolid used as part of regular treatment;
- Meropenem, vancomycin, ceftazidime, ceftriaxone, ceftizoxime and linezolid was administered intravenously.
Exclusion
- Patients who die within the treatment cycle;
- Severe congenital malformation;
- Receive other systemic experimental drug therapy;
- Other factors that the researchers consider unsuitable for inclusion.
Key Trial Info
Start Date :
October 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 20 2026
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT04771884
Start Date
October 1 2020
End Date
March 20 2026
Last Update
April 13 2021
Active Locations (1)
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1
Children's Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China, 400014