Status:
NOT_YET_RECRUITING
Mediterranean Diet and the Microbiota Gut Brain Axis in Major Depression
Lead Sponsor:
Medical University of Graz
Conditions:
Depression
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The purpose of this study is to assess the efficacy of a Mediterranean diet on the function of the vagal nerve in patients with depression.
Detailed Description
After being informed about the study and potential risks, all patients giving written informed consent will be screened for eligibility. Subjects meeting the inclusion criteria will be randomized in a...
Eligibility Criteria
Inclusion
- legally competent persons aged 18-80 years
- diagnosis of depression according to ICD-10 or DSM.
Exclusion
- other neurologic or psychiatric disorders (epilepsy, brain tumor, head injury, head surgery, trauma)
- drug or alcohol dependency
- acute suicidality
- heart disorders, disorders of the circulatory system
- pregnancy and period of breastfeeding
- severe mental disability, dementia (MMST\<20)
- autoimmune disorder, severe immunosuppression (Lupus, HIV, multiple sclerosis)
- therapy with antibiotics in the last month
- chronic laxative abuse
- acute infectious diarrhea
- GI surgeries (except appendectomy)
- regular intake of probiotics, antibiotics and food supplements (1 month before and during the study)
- food allergies or other food intolerances which are incompatible with a mediterranean diet
- vegetarians, vegans
Key Trial Info
Start Date :
November 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2029
Estimated Enrollment :
108 Patients enrolled
Trial Details
Trial ID
NCT04772651
Start Date
November 1 2025
End Date
September 30 2029
Last Update
March 14 2023
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.