Status:
RECRUITING
Effectiveness of High-frequency rTMS in Reducing Alcohol Consumption in Non-abstinent Patients With an Alcohol Use Disorder
Lead Sponsor:
Centre Hospitalier Universitaire Dijon
Conditions:
Alcoholism
rTMS Stimulation
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The fight against alcoholism is a public health priority. Around 15 million Europeans and 10 million North Americans are alcohol dependent. Worldwide, 1 death out of 25 is thought to be attributed to ...
Eligibility Criteria
Inclusion
- a person who has given his or her free, written and informed consent
- adult patient
- patient with mild to severe alcohol use disorder according to DSM-5 criteria
- voluntary patient to reduce alcohol consumption
- patient who has already made at least one attempt at alcohol withdrawal (failure or relapse), or at reducing consumption
Exclusion
- person who is not affiliated to or not a beneficiary of national health insurance
- person subject to a legal protection measure (curatorship, guardianship)
- person subject to a legal safeguard measure
- pregnant, parturient or breastfeeding women
- adult unable to express consent
- patient of childbearing age with a positive pregnancy test at inclusion
- patient with an exhaled alcohol level \> 0 milligrams/litre inclusive
- patient with heavy alcohol consumption \< 6 days in the 4 weeks prior to inclusion (European Medicine Agency, 2010; one day with alcohol consumption of 60g or more for men and 40g for women)
- patient with an average alcohol consumption below the WHO average risk level in the 4 weeks prior to inclusion (WHO, 2000, less than or equal to 40g/day for men and 40g for women)
- patient being abstinent more than 5 days before inclusion
- patient with a CIWA (Clinical Institute Withdrawal Evaluation: assessment of the severity of alcohol withdrawal) score greater than or equal to 10 at inclusion
- Patient with concomitant treatment with disulfiram, acamprosate, topiramate, baclofen, naltrexone, and nalmefen (\< 1 month)
- Patient with a history or presence of pre-delirium tremens or delirium tremens
- Patient with a substance use disorder (DSM-5 criteria) with psychoactive substances other than tobacco and alcohol.
- Patient with acute psychiatric disorders requiring hospitalization and/or immediate adjustment of psychotropic medication
- Patient with severe depression, defined by a score of 24 or more on the Hamilton Depression Scale (HAM-D).
- Patient who has had a recent change (\< 1 month) in the prescription of psychotropic treatment
- Patient with severe and/or chronic psychiatric disorders, including schizophrenia, paranoia and bipolar disorders type I and II
- Patient with severe heart, kidney, liver or lung failure or other condition that the doctor believes could compromise the patient's participation in the study.
- Patient with a contraindication to the practice of rTMS; personal history of seizure, pacemaker, neurosurgical clips, carotid or aortic clips, heart valves, hearing aid, ventricular bypass valve, sutures with wires or staples, foreign bodies in the eye, shrapnel, other prosthesis or cephalic ferromagnetic material.
- Patient simultaneously participating in another therapeutic trial
- Patient employed by the investigator or trial site
- Patient who, according to the investigator, is unable to complete a consumption diary and follow up visits for 6 months
- Patient refusing to sign the "safety contract "\* specific to the study
Key Trial Info
Start Date :
March 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2027
Estimated Enrollment :
144 Patients enrolled
Trial Details
Trial ID
NCT04773691
Start Date
March 1 2021
End Date
August 1 2027
Last Update
April 17 2025
Active Locations (1)
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1
Chu Dijon Bourogne
Dijon, France, 21000