Status:
UNKNOWN
A Combined Microdialysis and FDG-PET Study for Detection of Brain Injury After Cardiac Arrest
Lead Sponsor:
Odense University Hospital
Conditions:
Cardiac Arrest
Brain Injuries
Eligibility:
All Genders
18+ years
Brief Summary
Brain injury remains the leading cause of death in comatose patients resuscitated from OHCA. One of the most challenging aspects in the treatment of a post-cardiac arrest patient is the assessment of ...
Detailed Description
Background Survival rates around 50 % are reported in comatose patients treated with hypothermia in Intensive Care Unit (ICU) after out-of-hospital cardiac arrest (OHCA). The high risk of ICU death is...
Eligibility Criteria
Inclusion
- Out-of-hospital cardiac arrest (OHCA) of presumed cardiac cause
- Sustained return of spontaneous circulation (ROSC), defined as ROSC when chest compressions have not been required for 20 consecutive minutes and signs of circulation persist
- Unconsciousness (Glasgow Coma Scale (GCS) score of less than 8) after sustained ROSC
- Target temperature management (TTM) is indicated.
Exclusion
- Conscious patient (GCS score of at least 8)
- Female of child-bearing potential, unless a negative human chorionic gonadotropin (hCG) test can rule out pregnancy within the inclusion window
- In-hospital cardiac arrest (IHCA)
- OHCA of presumed non-cardiac cause, such as after trauma, dissection/rupture of major artery or arrest caused by hypoxia (i.e., drowning, hanging, etc.)
- Known bleeding diathesis (medically induced coagulopathy does not exclude patient)
- Suspected or confirmed acute intracranial bleeding
- Suspected or confirmed acute ischemic stroke
- Unwitnessed asystole
- Known limitations in therapy and do-not-resuscitate order
Key Trial Info
Start Date :
February 25 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2023
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT04774055
Start Date
February 25 2021
End Date
December 1 2023
Last Update
April 20 2022
Active Locations (1)
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1
Odense University Hospital
Odense, Fyn, Denmark, 5000