Status:
TERMINATED
Intensive Control of Blood Pressure in Acute Ischemic Stroke After Endovascular Therapy on Clinical Outcome (CRISIS I)
Lead Sponsor:
Nanjing First Hospital, Nanjing Medical University
Conditions:
Acute Ischemic Stroke
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
CRISIS I is a prospective, multicenter, randomized controlled trial, to asses the impact of intensive blood pressure control on clinical outcome of acute ischemic stroke patients with successful recan...
Detailed Description
CRISIS I aims to determine the effectiveness of more intensive BP lowering target (\<120 mmHg) compared to standard BP management target (\<140mmHg) on functional outcome in patients with successful r...
Eligibility Criteria
Inclusion
- Age ≥18 years
- Diagnosis of AIS with anterior circulation LVO confirmed by brain imaging
- To receive MT \<24 hours after AIS onset according to local guidelines
- Successful recanalization (TICI score ≥2b) after MT
- Sustained systolic BP ≥140 mmHg (defined as 2 successive readings \<10 mins) within 60 minutes after recanalization
- Provide written informed consent (or approved surrogate)
- Perform CTA or MRI before endovascular therapy
- Signed an approved informed consents
Exclusion
- Significant pre-stroke disability (mRS scores 2-5)
- Definite indication/contraindication to different intensities of BP lowering treatment
- Specific contraindications to any of the BP agents to be used (eg, patients who are hypersensitive (allergic) to any of the ingredients)
- Unlikely to potentially benefit from therapy (e.g. advanced dementia) or very high likelihood of death within 24 hours post-MT, judged by responsible treating clinician
- Other medical illness that interferes with outcome assessments and follow-up (e.g.advance cancer and renal failure); Women who are lactating
- Other conditions inappropriate for inclusion judged by investigators
Key Trial Info
Start Date :
July 3 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 3 2023
Estimated Enrollment :
205 Patients enrolled
Trial Details
Trial ID
NCT04775147
Start Date
July 3 2020
End Date
January 3 2023
Last Update
July 24 2023
Active Locations (1)
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1
Nanjing First Hospital, Nanjing Medical University
Nanjing, Jiangsu, China, 210006