Status:
COMPLETED
Allogeneic Mesenchymal Human Stem Cell Infusion Therapy for Endothelial DySfunctiOn in Diabetic Subjects With Symptomatic Ischemic Heart Disease. (ACESO-IHD)
Lead Sponsor:
Joshua M Hare
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Diabetes Mellitus
Ischemic Heart Disease
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
The purpose of this study is to test the hypothesis that allogeneic Mesenchymal Stem Cells (MSCs) promote systemic and coronary endothelial repair through rescue of bone marrow progenitors in type 2 d...
Eligibility Criteria
Inclusion
- Be ≥ 18 years of age (males and females).
- Provide written informed consent.
- Have a diagnosis of symptomatic ischemic heart disease (IHD) and an indication for standard-of-care coronary angiography.
- Have Diabetes Mellitus (DM) type 2 documented by glycated hemoglobin (HbA1C) \> 7%, or on medical therapy for diabetes.
Exclusion
- Be younger than 18 years of age.
- Have history of prior myocardial Infarction and revascularization.
- Have a baseline glomerular filtration rate (GFR) \<30 ml/min 1.73m2 estimated using the Modification of Diet for Renal Disease (MDRD) formula.
- Have poorly controlled blood glucose levels with hemoglobin A1C \> 8.5% in the previous 3 months.
- Have a history of proliferative retinopathy or severe neuropathy requiring medical treatment.
- Have an indication for standard-of-care surgical (including valve surgery, placement of left-ventricular assist device) or percutaneous intervention for the treatment of valvular heart disease (including valvuloplasty).
- Have known hypersensitivity or contraindication to aspirin; both heparin and bivalirudin; all available P2Y12 inhibitors (clopidogrel, prasugrel, and ticagrelor); or any zotarolimus, cobalt, chromium, nickel, tungsten, acrylic, or fluoropolymers; or hypersensitivity to contrast media that cannot be adequately premedicated.
- Have a hematologic abnormality as evidenced by hematocrit \< 25%, white blood cell \< 2,500/microliter (uL) or platelet values \< 100,000/uL without another explanation (per investigator discretion).
- Have liver dysfunction, as evidenced by enzymes (AST and ALT) greater than three times the upper limit of normal.
- Have a bleeding diathesis or coagulopathy (INR \> 1.3), cannot be withdrawn from anticoagulation therapy, or will refuse blood transfusions.
- Be an organ transplant recipient or have a history of organ or cell transplant rejection.
- Have a clinical history of malignancy within the past 5 years (i.e., subjects with prior malignancy must be disease free for 5 years), except curatively-treated basal cell or squamous cell carcinoma, or cervical carcinoma.
- Have a condition that limits lifespan to \< 1 year.
- Have a history of drug or alcohol abuse within the past 24 months.
- Be serum positive for HIV, hepatitis B surface antigen (sAg), or viremic hepatitis C.
- Be currently participating (or participated within the previous 30 days) in an investigational therapeutic or device trial.
- Be pregnant, nursing, or of childbearing potential and not on contraceptive medications. (May participate if on 2 forms of contraceptives).
- Any other condition that in the judgment of the Investigator would be a contraindication to enrollment or follow-up.
- Coronary lesions with restenosis or heavy calcification.
Key Trial Info
Start Date :
August 16 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 26 2025
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT04776239
Start Date
August 16 2021
End Date
August 26 2025
Last Update
September 2 2025
Active Locations (1)
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1
University of Miami
Miami, Florida, United States, 33136