Status:
COMPLETED
Assessing the Pharmacokinetics, Safety, Tolerability and Efficacy of Continuous Oral Levodopa Via the DopaFuse® Delivery System in Parkinson's Disease Patients
Lead Sponsor:
SynAgile Corporation
Collaborating Sponsors:
Clintrex Research Corporation
TFS Trial Form Support
Conditions:
Parkinson's Disease
Eligibility:
All Genders
30+ years
Phase:
PHASE2
Brief Summary
The purpose of this study is to evaluate whether the DopaFuse System can reduce the fluctuation of plasma levodopa levels compared to participants' standard intermittent doses of oral LD/CD tablets (b...
Eligibility Criteria
Inclusion
- Diagnosis of Parkinson's Disease consistent with UK Brain Bank Criteria
- Age at least 30 years old at time of consent
- Male and Female participants (Women of child-bearing potential (WOCB) are eligible for participation if they are not pregnant or breastfeeding and agree to follow the contraceptive guidance in Appendix 3 during the treatment period and for at least 30 days after the last dose of study treatment)
- Suitable for oral retainer wear
- A good response to Levodopa, as assessed by the Investigator
- At least 2 hours of wearing OFF time per day, as reported by the participant
- Predictable early morning OFF periods, in the judgement of the participant and the Investigator
- Taking 400-1,200 mg of LD/CD per day in at least 4 doses, with stable dosing for the last 28 days prior to screening.
- A modified Hoehn and Yahr of ≤ 3 in the ON state at screening
- A stable regimen of anti-PD medications for the last 28 days prior to Screening
- A Mini-Mental State Examination (MMSE) Score ≥26
- Capable of giving signed informed consent
- Approved for entry into the study by the Enrollment Authorization Committee (EAC)
Exclusion
- Atypical or secondary Parkinson's Disease
- Severe Dyskinesia that might interfere with study performance in the judgement of Investigator
- Clinically significant dysphagia or sialorrhea that might interfere with administration of study intervention in the judgement of the Investigator
- Use of extended release levodopa within 28 days prior to screening
- Any clinically significant medical, surgical, or psychiatric condition; laboratory value or ECG result which, in the opinion of the Investigator, makes the participant unsuitable for study entry or potentially unable to complete all aspects of the study.
- Presence of clinically significant orthostatic hypotension at screening, in the opinion of Investigator or the EAC
- Suicidal ideation within 1 year prior to the Screening Visit as evidenced by answering "yes" to Questions 4 or 5 on the suicidal ideation portion of the Columbia Suicide Severity Rating Scale (C-SSRS) or attempted suicide within the last 5 years.
- History of psychosis or hallucinations in the past six months
- Any malignancy in the past 5 years (excluding basal cell carcinoma of the skin or cervical carcinoma in situ that have been successfully treated.)
- Current or previous diagnosis of malignant melanoma or the presence of any suspicious skin lesion based on physical exam findings
- Unable to give blood required for the study
- History of allergic reaction to plastics
- LD infusion therapy (i.e. Duodopa); current or previous continuous apomorphine infusion treatment.
- Participation in any other clinical trial \<30 days prior to screening visit.
- Presence of two third molars ("wisdom teeth") on the upper dentition
- Participants who, for any reason, are judged by the Investigator or the EAC to be inappropriate for this study, including participants who are unable to communicate or cooperate with the Investigator or who have/had a clinically significant illness or abnormal physical examination that may compromise safety of the participant during the trial or affect ability of the participant to adhere to study procedures.
- Participants taking non-selective monoamine oxidase (MAO) inhibitors
- Participants with known hypersensitivity to the active ingredients (levodopa, carbidopa) or excipients (Benzoic Acid, Disodium Edetate, Medium Chain Triglycerides, Poloxamer 188) of the drug paste
- Participants with narrow-angle glaucoma
Key Trial Info
Start Date :
June 16 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 2 2022
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT04778176
Start Date
June 16 2021
End Date
August 2 2022
Last Update
August 10 2022
Active Locations (5)
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1
San Raffaele Cassino
Cassino, Italy, 03043
2
Centro Parkinson, Policlinico Tor Vergata
Rome, Italy, 00133
3
IRCCS San Raffaele Pisana
Rome, Italy, 00163
4
Centre Hospitalier de Luxembourg
Luxembourg, Luxembourg