Status:
UNKNOWN
Modulation of Endothelial Dysfonction Using Vitamin C in Septic Shock Patients
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Septic Shock
Eligibility:
All Genders
18+ years
Brief Summary
Compare the microcirculatory reactivity before and after a 30-minute intravenous infusion of 40 mg/kg vitamin C and evaluate intra-individual variation of hemodynamic parameters between T0 and T1.
Detailed Description
This is a transversal study allowing to compare the microcirculatory reactivity before and after a 30-minute intravenous infusion of 40 mg/kg vitamin C. Design: • A monocentric, open-label, transver...
Eligibility Criteria
Inclusion
- Age \> 18 years
- Septic shock patient, reanimated and stabilized defined as:
- Patients with sepsis (suspected infection + 2 SOFA points) according to the latest international and the need to receive norepinephrine to maintain an average blood pressure above 65 mmHg
- Patient supported for at least 6 hours, necessary for diagnostic management and hemodynamic optimization according to international standards and for less than 24 hours to limit confounding factors related to prolonged reanimation (sedation) and the empowerment of organ failures in general and vascular in particular. Hemodynamic stabilization will be defined as no increase in norepinephrine dosages
Exclusion
- Pregnant or nursing women,
- Participation in another intervention research involving the human person or exclusion period following a previous research involving the human person
- Ward or curative patient
- Moribund patient
- Estimated life expectancy less than 1 month
Key Trial Info
Start Date :
January 26 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2021
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04778605
Start Date
January 26 2021
End Date
July 1 2021
Last Update
March 3 2021
Active Locations (1)
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1
Intensive care department- Hôpital saint Antoine
Paris, France, 75012