Status:
UNKNOWN
First in Man Study of Implantable Alginate Hydrogel
Lead Sponsor:
Xijing Hospital
Conditions:
Heart Failure
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The objective of this clinical research is to evaluate the safety and effectiveness of Implantable Alginate Hydrogel to reconstruct the left ventricle in the treatment of heart failure
Eligibility Criteria
Inclusion
- The patients must have been able and willing to give written informed consent
- The patients should be adult (age≥ 18 years and \<75 years) males or females
- The patients must have been on stable, evidence-based therapy for HF
- The Patients have a LVEF ≤35%
- NYHA is classified as grade III or IV
- If female, the patients must have been (a) post-menopausal, (b) surgically sterile, or (c) using adequate birth control and have a negative serum pregnancy test within 7 days prior to administration of the study device.
Exclusion
- Have undergone any therapeutic traumatic heart surgery within 30 days.
- Hemodynamic instability or cardiogenic shock.
- Right-sided HF.
- Patients who presented with a restrictive cardiomyopathy such as due to amyloidosis, sarcoidosis, or hemochromatosis.
- History of Constrictive pericarditis.
- History of stroke (within 60 days prior to the surgical procedure).
- History of myocardial infarction (within 30 days prior to the surgical procedure).
- An LV wall thickness of the LV free-wall, at the mid-ventricular level, of \< 6 mm.
- Serum creatinine \> 2.0 mg/dL, or calculate creatinine clearance rate \<25 mL/min
- Clinically significant liver enzyme abnormalities, i.e., aspartate aminotransferase (AST) or alanine aminotransferase (ALT) more than 2 times the upper limit of normal and/or bilirubin more than 50% above the upper limit of normal.
- Had been receiving concurrently an investigational product in another clinical trial or had received an investigational product in another clinical trial in the 30 days prior to enrollment.
- A life expectancy of \< 1 year due to comorbidities .
- Unfit for the minimal invasive treatment.
Key Trial Info
Start Date :
April 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2023
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT04781660
Start Date
April 1 2021
End Date
January 1 2023
Last Update
March 4 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The First Affiliated Hospital of Air Force Military Medical University
Xi’an, Shanxi, China