Status:
UNKNOWN
Duloxetine vs Pregabalin for Thoracotomy Pain
Lead Sponsor:
Cairo University
Conditions:
Postoperative Pain
Eligibility:
All Genders
18-60 years
Phase:
PHASE4
Brief Summary
This study investigates the effects of preoperative use of oral combination of duloxetine and Pregabalin in comparison with preoperative oral Pregabalin only in treatment of acute postoperative and pr...
Detailed Description
75 Patients, undergoing thoracotomy surgery will be randomly allocated into three equal groups, each (n=25 ), using computerized generated random tables: Group P: will receive oral Pregabalin 75mg two...
Eligibility Criteria
Inclusion
- ● Physical status ASA II, III.
- Age ≥ 18 and ≤ 65 Years.
- Body mass index (BMI): \> 20 kg/m2 and \< 40 kg/m2.
- Cancer patients undergoing posterolateral thoracotomy incision for cancer lung, mesothelioma or metastatectomy from the lung.
- Patient is able to provide a written informed consent.
Exclusion
- ● Patients with Known sensitivity or contraindication to drug used in the study
- History of psychological disorders and/or chronic pain.
- Previous administration of antidepressants, anticonvulsants, or opioids before surgery.
- Patient refusal.
- Severe respiratory or cardiac disorders.
- Advanced liver or kidney disease.
Key Trial Info
Start Date :
March 10 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 15 2021
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT04782310
Start Date
March 10 2021
End Date
September 15 2021
Last Update
June 2 2021
Active Locations (1)
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1
Bassant abdelhamid
Cairo, Egypt, 1772