Status:
ACTIVE_NOT_RECRUITING
Volumetrics and Proteomics in Shunted Normal Pressure Hydrocephalus
Lead Sponsor:
University Hospital, Linkoeping
Conditions:
Hydrocephalus, Normal Pressure
Ventriculomegaly, Cerebral
Eligibility:
All Genders
Phase:
NA
Brief Summary
Idiopathic normal pressure hydrocephalus (=iNPH) is a condition with disturbed circulation of cerebrospinal fluid (=CSF) causing symptoms such as balance and gait disorders, urinary incontinence and c...
Detailed Description
BACKGROUND \& SUMMARY DESCRIPTION OF THE PROJECT Idiopathic normal pressure hydrocephalus (=iNPH) is a condition with disturbed cerebral dynamics causing symptoms in the form of balance and gait diso...
Eligibility Criteria
Inclusion
- FOR iNPH-PATIENTS:
- INCLUSION CRITERIA:
- Must meet the clinical criteria for iNPH according to the International Guide lines of 2005
- Must undergo shunt implantation at the Dpt of Neurosurgery Linköping University Hospital.
- EXCLUSION CRITERIA:
- Individuals not able to participate/cooperate in study tasks with regard to cognitive symptoms
- Individuals with claustrophobia that makes awake MRI examination impossible.
- Individuals with implants that make MRI examination impossible (for instance pacemaker, refers only to the MRI examinations included in the study).
- Patients with severe co-existing chronical neurological diseases (refers only to the proteomic examinations included in the study).
- FOR CONTROL GROUP VOLUNTEERS:
- INCLUSION CRITERIA:
- Must undergo surgery under spinal anesthesia at the Dpt of Orthopaedics, Urology or Gynaecology at the University Hospital Linkoping.
- Must consider themselves neurologically healthy and have not undergone neurological disease.
- EXCLUSION CRITERIA:
- Individuals with claustrophobia that makes awake MRI examination impossible.
- Individuals with implants that make MRI examination impossible
- Individuals with malignant disease or oncological treatment for such disease.
- Individuals with neurological disorders detected after study MRI.
Exclusion
Key Trial Info
Start Date :
March 8 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2025
Estimated Enrollment :
58 Patients enrolled
Trial Details
Trial ID
NCT04785560
Start Date
March 8 2021
End Date
July 1 2025
Last Update
April 3 2024
Active Locations (1)
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1
Neurosurgical department University Hospital Linköping
Linköping, Sweden, 58185