Status:
COMPLETED
Norepinephrine vs Phenylephrine During General Anesthesia
Lead Sponsor:
University of California, San Francisco
Conditions:
Anesthesia
Surgery
Eligibility:
All Genders
18-99 years
Phase:
PHASE4
Brief Summary
50 million patients undergo surgery each year in the United States. Postoperative mortality is considered the third leading cause of death worldwide. Hypotension during surgery have been linked to inc...
Detailed Description
Postoperative mortality is considered the third leading cause of death worldwide. Hemodynamic instability and specifically hypotension during surgery have been linked to increased postoperative morbid...
Eligibility Criteria
Inclusion
- age 18 Years and older
- Surgery under general anesthesia and requiring infusion of vasopressors to maintain the mean arterial pressure.
- Surgery duration\>2 hours
Exclusion
- Cardiac surgery
- Patients on ECMO
- Organ transplantation
- Outpatient (come-and-go surgery)
- Obstetric procedures
- Patient already receiving NE or PE before induction of anesthesia
- Patients transferred immediately (i.e. within 24 hours) after surgery to another hospital.
- Patients with severe trauma
Key Trial Info
Start Date :
July 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2022
Estimated Enrollment :
3626 Patients enrolled
Trial Details
Trial ID
NCT04789330
Start Date
July 1 2021
End Date
April 1 2022
Last Update
December 18 2025
Active Locations (5)
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1
Ronald Reagan UCLA Medical Center
Los Angeles, California, United States, 90095
2
Zuckerberg San Francisco General Hospital
San Francisco, California, United States, 94110
3
UCSF Medical Center at Mount Zion
San Francisco, California, United States, 94115
4
UCSF Medical Center at Parnassus
San Francisco, California, United States, 94143