Status:
COMPLETED
Smell in Covid-19 and Efficacy of Nasal Theophylline
Lead Sponsor:
Washington University School of Medicine
Conditions:
Covid19
Anosmia
Eligibility:
All Genders
18-70 years
Phase:
PHASE2
Brief Summary
Evidence of COVID-19 related anosmia and dysgeusia continues to accumulate daily. Currently, up to 80% of patients report subjective olfactory dysfunction (OD), and prevalence using objective olfacto...
Detailed Description
Post-viral olfactory dysfunction has numerous known adverse effects such as loss of cortical gray matter and decrease in quality of life. COVID-19 related olfactory dysfunction has already been shown ...
Eligibility Criteria
Inclusion
- Olfactory dysfunction that has persisted for \>3 months following suspected COVID-19 infection
- Residing within the states of Missouri or Illinois.
- Can read, write, and understand English.
Exclusion
- History of olfactory dysfunction prior to COVID-19 infection
- Use of concomitant therapies specifically for the treatment of olfactory dysfunction
- History of olfactory dysfunction longer than 12 months
- Known existence of nasal polyps, prior sinonasal, or anterior skull-based surgery
- Dependence on theophylline for comorbid conditions such as asthma and COPD
- History of an allergic reaction to theophylline or other methylxanthines
- History of neurodegenerative disease (ie. Alzheimer's dementia, Parkinson's disease, Lewy body dementia, frontotemporal dementia)
- Pregnant or breastfeeding mothers
- Current use of medications with significant interactions with theophylline, which include cimetidine, ciprofloxacin, disulfiram, enoxacin, fluvoxamine, interferon-alpha, lithium, mexiletine, phenytoin, propafenone, propranolol, tacrine, thiabendazole, ticlopidine, and troleandomycin.
- Pre-existing arrhythmias or seizures
Key Trial Info
Start Date :
March 15 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 30 2021
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT04789499
Start Date
March 15 2021
End Date
December 30 2021
Last Update
May 24 2023
Active Locations (1)
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1
Washington University School of Medicine in Saint Louis
St Louis, Missouri, United States, 63110