Status:
UNKNOWN
Efficacy of Oral Verapamil and Oral Diltiazim on Reduction of Intraoperative Bleeding During Endoscopic Sinus Surgery Under General Anesthesia
Lead Sponsor:
Assiut University
Conditions:
Verapamil
Diltiazim
Eligibility:
All Genders
18-60 years
Phase:
EARLY_PHASE1
Brief Summary
To study the effect of addition of oral verapamil or Diltiazim to general anaesthesia on the Intraoperative haemodynamics : heart rate(HR), noninvasive blood pressure(NIBP), mean arterial blood pressu...
Detailed Description
Functional Endoscopic Sinus Surgery (FESS) is a minimally invasive technique used to restore sinus ventilation and function in patients with recurrent acute or chronic infective sinusitis in whom medi...
Eligibility Criteria
Inclusion
- Age of 18 - 60 years.
- patients of both genders.
- ASA grade I - II.
Exclusion
- Patient refusal.
- Any contraindication of B- blocker:
- Athma , COPD
- Bradycardia , Heart block
- Acute decompensated heart failure
- Peripheral vascular disease
- Any contraindication of calcium channel blocker:
- AV conduction defects (2nd and 3rd degree AV block).
- Sick sinus syndrome .
- Wolf-Parkinson-White Syndrome.
- History of congestive heart failure.
- Patients on long-term ß-blocker therapy.
- Patients with allergy to medication included in the study.
Key Trial Info
Start Date :
March 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 20 2022
Estimated Enrollment :
135 Patients enrolled
Trial Details
Trial ID
NCT04790331
Start Date
March 1 2021
End Date
January 20 2022
Last Update
March 10 2021
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