Status:
UNKNOWN
Effect of Berberine Hydrochloride on Blood Pressure and Vascular Endothelial Function in Patients With Hypertension
Lead Sponsor:
Jun Tao
Conditions:
Hypertension
Endothelial Dysfunction
Eligibility:
All Genders
18-75 years
Phase:
PHASE4
Brief Summary
Hypertension is a progressive cardiovascular syndrome caused by multiple causes, which can lead to changes in the function and structure of the heart and blood vessels. It is the leading risk factor o...
Eligibility Criteria
Inclusion
- Essential hypertension (office blood pressure: systolic blood pressure 140-159 mmHg and/or diastolic blood pressure 90-99 mmHg
- 18 to 75 years old
- No drugs or dietary supplements that affect blood pressure and vascular endothelial function have been used in the past 3 months, mainly including antihypertensive, lipid-lowering, hypoglycemic drugs and natural plant extract antioxidants
- Individuals who voluntarily sign the consent form after being fully informed and understanding the purpose and procedure of the study, characters of the disease, drug effects, methods of related examinations, and potential risk/benefits of the study
Exclusion
- Individuals with secondary blood pressure rise factors
- Individuals who are hypersensitive or intolerant to the drugs
- Individuals presenting severe constipation
- Individuals with severe heart disease, abnormal liver and kidney function, acute and chronic infections, autoimmune diseases and patients with any history of cancer
- Individuals with mental diseases who are not able to cooperate
- Pregnant women, women during breast-feeding period, or women with expect pregnancy
- Individuals with hemolytic anemia and glucose-6 phosphate dehydrogenase deficiency
Key Trial Info
Start Date :
October 22 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 22 2022
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04790942
Start Date
October 22 2020
End Date
May 22 2022
Last Update
March 10 2021
Active Locations (1)
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1
Jun Tao
Guangzhou, Guangdong, China, 510080