Status:
RECRUITING
Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes
Lead Sponsor:
University of Colorado, Denver
Collaborating Sponsors:
University of Virginia
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Type 2 Diabetes
Overweight and Obesity
Eligibility:
All Genders
30-55 years
Phase:
NA
Brief Summary
The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal...
Detailed Description
It is our goal to determine whether exercise training attenuates insulin resistance and restores insulin-mediated perfusion to the heart and to skeletal muscle, leading to improved cardiac function an...
Eligibility Criteria
Inclusion
- Sedentary (defined as less than 1 hour per week of physical activity)
- BMI: 25-40
- Men and women with and without type 2 diabetes
Exclusion
- Documented cardiovascular disease
- Uncontrolled hypertension: disease systolic blood pressure (SBP) \> 150, diastolic blood pressure (DBP)\> 110
- Obstructive pulmonary disease or asthma
- Peripheral neuropathy
- Physical impairment that would limit exercise ability
- Subjects taking beta blockers, calcium channel blockers, insulin, or Thiazolidinediones (TZD)
- Current or past smoking within the last 1 years
- Current tobacco use
- Anemia
- Control HbA1c \> 5.7, T2DM HbA1c \> 9
- Pregnant, nursing or hormonal therapy (other than contraceptives)
- Peri or post-menopausal women
- Type 1 diabetes
- Hepatic or renal disease.
Key Trial Info
Start Date :
June 17 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2027
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT04791371
Start Date
June 17 2022
End Date
December 1 2027
Last Update
March 12 2025
Active Locations (2)
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1
University of Colorado
Aurora, Colorado, United States, 80045
2
University of Virginia
Charlottesville, Virginia, United States, 22908