Status:
UNKNOWN
NAVA vs PSV Ventilation During Weaning From Mechanical Ventilation in Children After Liver Transplantation
Lead Sponsor:
Bambino Gesù Hospital and Research Institute
Collaborating Sponsors:
Catholic University of the Sacred Heart
Conditions:
Pediatric Liver Transplantation
Weaning From Mechanical Ventilation
Eligibility:
All Genders
1-10 years
Phase:
NA
Brief Summary
Liver transplantation is the treatment of choice for acute and chronic end-stage liver disease. Neurally Adjusted Ventilator Assist (NAVA) may be a feasible solution to guide the liberation from mecha...
Detailed Description
Twelve pediatric patients underwent liver transplantation and admitted during postoperative period in PICU will be studied. They will be endotracheally intubated and spontaneously triggering the mecha...
Eligibility Criteria
Inclusion
- Liver recipients (from cadaveric or living donor)
- Invasive Mechanical ventilation
Exclusion
- Neurological impairment
- Neuromuscular, mitochondrial, metabolic, or chromosomal diseases with baby hypotonia
- Lesions of medulla
- Hemodynamic instability requiring inotropes/vasopressors (dopamine \> 6 mcg/kg/min, norepinephrine, epinephrine, dobutamine, milrinone) or volume load.
- Congenital cardiovascular disease
- Patient extubated
- Need of controlled mechanical ventilation
- Intravenous infusion of benzodiazepines or propofol
- Pneumonia, pneumothorax, massive pleural effusion
- Patient placed on extracorporeal circuit
- Contraindications to insert nasogastric tube
- Not expected to survive beyond 24 hours
- Parental/legal guardian refusal
Key Trial Info
Start Date :
September 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 30 2022
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT04792788
Start Date
September 1 2020
End Date
January 30 2022
Last Update
October 22 2021
Active Locations (1)
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1
Fabrizio Chiusolo
Rome, RM, Italy, 00165