Status:
COMPLETED
Preventive Potential of Bilirubin
Lead Sponsor:
University of Vienna
Collaborating Sponsors:
Medical University of Vienna
Conditions:
Mild Hyperbilirubinaemia
Eligibility:
All Genders
20-80 years
Brief Summary
The prevalence of mild hyperbilirubinemia, also known as Gilbert´s Syndrome, is usually defined using an unconjugated bilirubin (UCB) blood concentration above 17.1 µmol/l. The prevalence of GS is rem...
Eligibility Criteria
Inclusion
- In general
- Signed declaration of consent
- Age: 20-80 years
- Liver enzymes (AST, ALT, GGT) \< 1.5x over norm values
- Non smoking
- Moderate physical activity
- Ability to communicate with the study team in the local language to understand the study procedure
- Cases (GS):
- Total blood bilirubin \> 1.2 mg/dl
- Unconjugated bilirubin \> 1 mg/dl
- Controls (non-GS):
- Total blood bilirubin ≤ 1.2 mg/dl
- Unconjugated bilirubin ≤ 1 mg/dl
Exclusion
- In general
- Age \< 20 or \> 80 years
- Cardiovascular diseases
- Liver diseases (including Hep B and C)
- Cholelithiasis
- Hemolysis
- Renal diseases
- Active tumors
- Diabetes mellitus
- Smoking
- Professional athletes
- Subjects with organ transplants
- Intake of antioxidants within the last 4 weeks
- Intake of liver influencing medication within the last 5 weeks
- Cases (GS):
- Total blood bilirubin ≤ 1.2 mg/dl
- Unconjugated bilirubin ≤ 1 mg/dl
- Controls (non-GS):
- Total blood bilirubin \> 1.2 mg/dl
- Unconjugated bilirubin \> 1 mg/dl
Key Trial Info
Start Date :
June 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2016
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT04792996
Start Date
June 1 2014
End Date
June 1 2016
Last Update
March 11 2021
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