Status:
ENROLLING_BY_INVITATION
Underlying Mechanisms of Obesity-induced Obstructive Sleep Apnea
Lead Sponsor:
Brandon Nokes
Conditions:
Obstructive Sleep Apnea
Obesity
Eligibility:
All Genders
18-65 years
Brief Summary
Obesity is a common risk factor for the development of obstructive sleep apnea. However, not all subjects with obesity develop obstructive sleep apnea. This study will attempt to determine the mechani...
Detailed Description
Obstructive sleep apnea (OSA) is a highly prevalent disease with major neurocognitive and cardiovascular sequelae. Obesity is a major risk factor for OSA, but the underlying mechanisms remain unclear....
Eligibility Criteria
Inclusion
- \- Men and women
- Ages \>= 18-65 years old
- BMI 35 kg/m2--and above
- Scheduled for sleeve gastrectomy (bariatric surgery)
Exclusion
- Any cardiovascular, pulmonary or renal disease other than well-controlled hypertension or asthma.
- Pregnancy
- Currently smoking
- Any respiratory disorder other than OSA or well controlled asthma
- contraindication to MRI
Key Trial Info
Start Date :
March 20 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 31 2026
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT04793334
Start Date
March 20 2021
End Date
May 31 2026
Last Update
May 29 2024
Active Locations (1)
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1
UCSD - Altman Clinical Research Institute (ACTRI)
La Jolla, California, United States, 92037