Status:
COMPLETED
Serum Soluble ST2 and Plaque Vulnerability in Patients With Acute Coronary Syndrome
Lead Sponsor:
RenJi Hospital
Conditions:
Acute Coronary Syndrome
Eligibility:
All Genders
18-75 years
Brief Summary
This study aimed to assess the association between serum sST2 level and plaque vulnerability in ACS patients. It is hypothesized that serum sST2 level may be related to plaque components and closely a...
Detailed Description
Serum soluble suppression of tumorigenicity-2 (sST2) has emerged as a novel biomarker of atherosclerotic disease. This study aimed to investigate whether elevated serum sST2 level is related to corona...
Eligibility Criteria
Inclusion
- Clinical diagnosis of non-ST-elevation ACS
- Non-ST-elevation myocardial infarction
- Unstable angina
- Age from 18 to 75 years
- Underwent CCTA
Exclusion
- Patients needed an immediate (\< 2 h) or early invasive strategy (\< 24 h) according to guidelines:
- Haemodynamic instability
- Cardiogenic shock
- Life-threatening arrhythmias or cardiac arrest
- Mechanical complication
- Acute heart failure
- Dynamic ST or T wave changes
- GRACE score \> 140
- Patients with previous history of:
- Coronary artery bypass graft surgery or percutaneous coronary intervention (PCI)
- Immune system disorder
- Tumor
- Acute/chronic infection
- Statin use within 3 months
- Atrial fibrillation
- End-stage renal failure
- Iodine-containing contrast allergy
- Patients with no significant (≥ 50%) stenosis on major epicardial vessels after CCTA performance
- Patients refused subsequent angiography after CCTA performance
- Patients with total obstruction on major epicardial vessel
- Patients with insufficient image quality for QAngioCT analysis
Key Trial Info
Start Date :
January 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2019
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT04797819
Start Date
January 1 2019
End Date
December 31 2019
Last Update
March 24 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Cardiology, Ren Ji Hospital
Shanghai, China