Status:
UNKNOWN
Effect of Exercise on GDF-15 Levels in Prediabetic Patients
Lead Sponsor:
Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Conditions:
PreDiabetes
Eligibility:
FEMALE
30-50 years
Phase:
NA
Brief Summary
The aim of this study is to evaluate whether there is a change in GDF-15 levels in individuals with prediabetes at the 2nd hour after the first exercise and after a 12-week exercise program with guide...
Detailed Description
GDF-15, which has anorexigenic effects, increases with exercise. In prediabetic patients, GDF-15 is higher than healthy controls. The effect of exercise on GDF-15 levels in prediabetic patients is unk...
Eligibility Criteria
Inclusion
- Body mass index 30-34.9 kg / m2
- Sedentary life-style (Physical activity below 300 kcal / day will be assessed by Minnesota Leisure Physical Activity Questionnaire)
- Those who have sufficient motivation to participate in the exercise program (will be evaluated by face-to-face interview by the researchers)
- Having the same weight for 6 months before participating in the study (± 2.5 kg)
- Those diagnosed with prediabetes by oral glucose tolerance test and / or HbA1c measurement will be included.
Exclusion
- Serious medical condition (e.g. advanced malignancy or major neurological, psychiatric or endocrine disease, respiratory failure, etc.)
- Having cardiovascular disease
- Having diabetes
- Using metformin
- Taking hormone replacement therapy
- less than 1 year life expectancy
- HIV positivity
- Substance use
- Functional dependence
- Cognitive weakness
- Those with other diseases that will affect the study result (respiratory diseases, muscle diseases, etc.)
- Those who use drugs or supplements that will affect the results of the study
Key Trial Info
Start Date :
April 15 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2023
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT04799938
Start Date
April 15 2021
End Date
April 1 2023
Last Update
June 22 2022
Active Locations (1)
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1
Sultan Abdülhamid Han Training and Research Hospital
Istanbul, Turkey (Türkiye)