Status:
RECRUITING
The Role Of Circulating Tumor Cells As Markers Of Advanced Disease And Prognosis In HCC
Lead Sponsor:
University of Milano Bicocca
Collaborating Sponsors:
Università degli Studi del Piemonte Orientale Amedeo Avogadro
Niguarda Hospital
Conditions:
Hepatocellular Carcinoma
Recurrent Hepatocellular Carcinoma
Eligibility:
All Genders
18+ years
Brief Summary
Hepatocellular carcinoma (HCC) recurs in up to 60% of patients who undergo resection. Circulating tumor cells (CTC) have been advocated as promotors of the recurrence. However, their role as prognosti...
Detailed Description
Liquid biopsy may allow a better stratification of patients according to their estimated prognosis. As well in other tumors (e.g. breast cancer), molecular characterization is permitting not only to b...
Eligibility Criteria
Inclusion
- Hepatocarcinoma diagnosis confirmed by radiology and committed to surgery (resection or OLT) with curative intent.
- First diagnosis and first treatment of hepatocellular carcinoma.
- BCLC 0 - A - B
- Histological confirmation of hepatocarcinoma at the histological specimen.
- Availability of a fresh frozen section of the tumor obtained during the surgical procedures
Exclusion
- Other tumors in the clinical history.
- Presence of autoimmune liver diseases (eg. sclerotising cholangitis, primary biliary cirrhosis etc.).
- Patients treated with surgery in case of not-curative intent (palliation, best supportive care, etc).
- Histopathological specimen of combined liver primary neoplasms (e.g. 'epatocolangiocarcinoma').
- Patients previously treated for HCC with other therapies
Key Trial Info
Start Date :
February 7 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 7 2026
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT04800497
Start Date
February 7 2019
End Date
February 7 2026
Last Update
January 17 2024
Active Locations (4)
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1
Ospedale San Gerardo
Monza, MB, Italy, 20900
2
ASST Grande Ospedale Metropolitano Niguarda
Milan, Italy
3
Università del Piemonte Orientale
Novara, Italy
4
Humanitas Research Hospital
Rozzano, Italy