Status:
COMPLETED
The Afolabi Stroke Registry for Children and Young Adults With SCD in Northern Nigeria
Lead Sponsor:
Vanderbilt University Medical Center
Collaborating Sponsors:
Aminu Kano Teaching Hospital
Murtala Muhammed Specialist Hospital
Conditions:
Sickle Cell Disease
Stroke
Eligibility:
All Genders
5-26 years
Brief Summary
Sickle Cell Anemia (SCA) occurs in 300,000 newborns per year in the world, with 150,000 affected births in Nigeria, alone. With improvement in survival for children with SCA in both high- and low-reso...
Detailed Description
The study is a multi-center, prospective observational cohort study. Thus, it is designed to be a longitudinal registry of strokes in children and young adults with SCA in Nigeria. Participants will b...
Eligibility Criteria
Inclusion
- Participants with sickle cell disease confirmed with hemoglobin electrophoresis or HPLC
- Age 5 to 26 years old
- Present within three months of stroke event that is diagnosed as a stroke by the local health care provider
- Medical records are available for review for the stroke event that occurred within 3 months
- Prior treatment in the SPIN, SPRING and SPRINT trials for primary or secondary stroke prevention
Exclusion
- Participants judged to be non-compliant by the hematologist based on previous experience in terms of clinic appointments and following advice
- Participants with contraindications to MRI, including individuals with MRI- incompatible foreign metal objects
Key Trial Info
Start Date :
April 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2023
Estimated Enrollment :
350 Patients enrolled
Trial Details
Trial ID
NCT04800809
Start Date
April 1 2020
End Date
December 31 2023
Last Update
April 23 2024
Active Locations (3)
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1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232-9000
2
Jamil Galadanci
Kano, Nigeria, PMB 3452
3
Aminu Kano Teaching Hospital
Kano, Nigeria