Status:
COMPLETED
Chronic Pain, Opioid Use, and Epidermal Nerve Fiber Density
Lead Sponsor:
University of Kansas Medical Center
Conditions:
Chronic Pain
Opioid Use
Eligibility:
All Genders
18-65 years
Brief Summary
This pilot study is being performed to examine whether epidermal axons are altered in patients taking opioid therapy for chronic non-cancer pain, and if epidermal axonal changes predict heightened pai...
Detailed Description
Currently, 1 in 25 adults in the USA regularly uses prescription opioids. Now described as a healthcare crisis, increased prescription opioid use is linked with greater healthcare utilization and its ...
Eligibility Criteria
Inclusion
- Healthy/All:
- Informed consent provided by the participant
- Able to read and speak in English
- Age 18 to 65 years
- Likely to participate in all scheduled evaluations and study procedures
- IF they are a Chronic Non-Cancer Patients who do NOT take opioid medication they must meet all of the above criteria as well as:
- Diagnosis of non-cancer chronic pain syndrome (persistent pain lasting longer than 3 months)
- IF they are a Chronic Non-Cancer Patients who DO take opioid medication they must meet all of the above criteria as well as:
- Chronic daily opioid use for longer than 3 months duration
- Stable doses of opioid medications for at least 30 days prior to study visit
Exclusion
- Pregnancy
- Prisoner
- Current clinically significant cardiac, or neurologic disease
- Significant skin disorders in lower extremities
- Circulatory insufficiency
- Open wounds in lower extremity that may interfere with healing
- Lidocaine allergy
- Currently taking anticoagulation (e.g., Coumadin, Plavix, etc)
- Current litigation for chronic pain
- Active psychotic or suicidal symptoms
- Current drug or alcohol abuse
- Neuropathy in upper extremities (hands specifically, PI discretion).
- Current or recent use of artificial fingernails or nail enhancements (last 6 months)
- Other diagnoses that are not considered minor/stable (PI discretion)
- Current or previous cancer diagnosis
- Current or previous chemotherapy treatment
- No chronic pain conditions (healthy)
- Opioid use in the last year (healthy \& non-opioid pts)
Key Trial Info
Start Date :
December 7 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 25 2024
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT04801498
Start Date
December 7 2020
End Date
June 25 2024
Last Update
November 6 2024
Active Locations (1)
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1
University of Kansas Health System
Kansas City, Kansas, United States, 66160