Status:
COMPLETED
Fluid Balance Neutralization During CRRT (Continuous Renal Replacement Therapy)
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Fluid Overload
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Fluid overload is associated with increased mortality in critically ill patients with acute kidney injury. Fluid balance controlled is associated with improved outcome in observational studies, and is...
Eligibility Criteria
Inclusion
- Patient 18 yo or more, affiliated to a social security system
- Treated with vasopressors for acute circulatory failure
- With KDIGO stage 3 acute kidney injury
- Treated with continuous renal replacement therapy for less than 24 jours
- Monitored with a calibrated continuous cardiac output device
Exclusion
- Treatment by ECMO (extracorporeal membrane oxygenation)
- Active hemorrhage necessitating transfusion
- Maintenance dialysis or renal graft recipient
- Switch to intermittent hemodialysis is scheduled in the next 72 hours
- Acute cerebral stroke complicated by coma and under mechanical ventilation
- Acute fulminant hepatitis
- Postural maneuver (passive leg raising or Trendelenburg) cannot be performed (amputation, inferior vena cava obstruction)
- Pregnancy or lactating
- Withdrawal or limitation of care
- Moribund patient
- Patient under protective measures/wardship
- Inclusion in another trial whose main outcome is cumulative fluid balance, or whose intervention targets hemodynamic physiology, fluid balance or net ultrafiltration.
- Patient previously enrolled in the same study
Key Trial Info
Start Date :
June 30 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 14 2023
Estimated Enrollment :
65 Patients enrolled
Trial Details
Trial ID
NCT04801784
Start Date
June 30 2021
End Date
July 14 2023
Last Update
November 21 2025
Active Locations (1)
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1
Hospices Civils de Lyon - Hôpital de la Croix Rousse
Lyon, France, 69004