Status:
ACTIVE_NOT_RECRUITING
The TreEat Study- Can Early Introduction of Tree Nuts Prevent Tree Nut Allergy in Infants with Peanut Allergy
Lead Sponsor:
Murdoch Childrens Research Institute
Conditions:
Food Allergy in Infants
Nut Allergy
Eligibility:
All Genders
4-11 years
Phase:
PHASE3
Brief Summary
Early and regular ingestion of the common allergens, peanut and egg has been shown to be an effective allergy prevention strategy. It is not clear whether this is also true of tree nut allergy. Curren...
Eligibility Criteria
Inclusion
- Infants aged greater than 4 months and less than 11 months of age diagnosed with IgE-mediated peanut allergy in conjunction with a positive SPT (≥3mm) or sIgE (specific immunoglobulin E) (\>0.35 kU/L)
Exclusion
- Any history of severe food induced anaphylaxis. Defined as reaction requiring 2 doses of intramuscular (IM) adrenaline.
- Pre-existing tree nut allergy (parent-reported).
- Any tree nut already tolerated (ingestion on \>3 occasions without reaction of around 1 teaspoon)
- SPT or sIgE performed to any tree nuts
- Not commenced or unable to eat solid food
- Prescribed beta-blocker medication
Key Trial Info
Start Date :
June 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2025
Estimated Enrollment :
212 Patients enrolled
Trial Details
Trial ID
NCT04801823
Start Date
June 1 2021
End Date
November 1 2025
Last Update
November 21 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Murdoch Children's Research Institute (MCRI)
Melbourne, Victoria, Australia, 3052